NOD2 |
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Estructures disponibles |
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PDB | Cerca ortòloga: PDBe RCSB |
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Llista de codis id de PDB |
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5IRL, 5IRM, 5IRN |
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Identificadors |
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Àlies | NOD2 (HUGO), ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS |
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Identif. externs | OMIM: 605956 MGI: 2429397 HomoloGene: 11156 GeneCards: NOD2 OMA: NOD2 - orthologs |
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Malalties relacionades genèticament |
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malaltia de Crohn, malaltia inflamatòria intestinal, Síndrome de Blau, enteritis, colitis ulcerosa [1] |
Localització del gen (humà) |
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| Crom. | Cromosoma 16 (humà)[2] |
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| Banda | 16q12.1 | Inici | 50.693.588 bp[2] |
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Fi | 50.734.041 bp[2] |
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Localització del gen (ratolí) |
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| Crom. | Cromosoma 8 (ratolí)[3] |
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| Banda | 8|8 C3 | Inici | 89.373.943 bp[3] |
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Fi | 89.415.102 bp[3] |
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Ontologia genètica |
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Funció molecular | - Hsp90 protein binding
- unió de nucleòtids
- Hsp70 protein binding
- unió proteica
- peptidoglycan binding
- enzyme binding
- actin binding
- CARD domain binding
- unió d'ATP
- protein kinase binding
- muramyl dipeptide binding
- protein-containing complex binding
| Component cel·lular | - citoplasma
- citosol
- vesícula
- membrana
- membrana plasmàtica
- superfície cel·lular
- membrana plasmàtica basolateral
- COP9 signalosome
- citoesquelet
- aparell de Golgi
- mitocondri
- complex macromolecular
| Procés biològic | - positive regulation of prostaglandin-endoperoxide synthase activity
- regulation of apoptotic process
- defense response
- detection of biotic stimulus
- cytokine production involved in immune response
- positive regulation of cytokine production involved in inflammatory response
- intracellular signal transduction
- detection of muramyl dipeptide
- positive regulation of interleukin-10 production
- positive regulation of epithelial cell proliferation
- procés del sistema immunitari
- positive regulation of oxidoreductase activity
- response to muramyl dipeptide
- positive regulation of prostaglandin-E synthase activity
- positive regulation of JNK cascade
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of NIK/NF-kappaB signaling
- positive regulation of phosphatidylinositol 3-kinase activity
- positive regulation of gamma-delta T cell activation
- cellular response to muramyl dipeptide
- JNK cascade
- negative regulation of macrophage apoptotic process
- positive regulation of dendritic cell antigen processing and presentation
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- maintenance of gastrointestinal epithelium
- defense response to bacterium
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of interleukin-8 production
- detection of bacterium
- positive regulation of interleukin-1 beta production
- regulation of inflammatory response
- positive regulation of interleukin-6 production
- protein complex oligomerization
- positive regulation of tumor necrosis factor production
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of B cell activation
- positive regulation of interleukin-17 production
- positive regulation of type 2 immune response
- nucleotide-binding oligomerization domain containing signaling pathway
- positive regulation of stress-activated MAPK cascade
- positive regulation of Notch signaling pathway
- positive regulation of transcription by RNA polymerase II
- cellular response to organic cyclic compound
- positive regulation of cell population proliferation
- sistema immunitari innat
- response to nutrient
- positive regulation of dendritic cell cytokine production
- positive regulation of protein K63-linked ubiquitination
- cellular response to peptidoglycan
- positive regulation of MAP kinase activity
- interleukin-1-mediated signaling pathway
- cellular response to lipopolysaccharide
| Fonts:Amigo / QuickGO |
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Ortòlegs |
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Espècies | Humà | Ratolí |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (ARNm) | |
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NM_001293557 NM_022162 NM_001370466 |
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RefSeq (proteïna) | |
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NP_001280486 NP_071445 NP_001357395 |
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Localització (UCSC) | Chr 16: 50.69 – 50.73 Mb | Chr 8: 89.37 – 89.42 Mb |
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Cerca a PubMed | [4] | [5] |
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Wikidata |
Veure/Editar gen humà | Veure/Editar gen del ratolí |
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