Acotiamide
Chemical compound
- A03FA10 (WHO) QA03FA10 (WHO)
- JP: Rx-only
- N-{2-[bis(1-Methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide
- 185106-16-5 N
- 5282338
- 4445505 Y
- D42OWK5383
- D08838 N
- ChEMBL2107723 N
- DTXSID40870163
- Interactive image
- O=C(Nc1nc(C(=O)NCCN(C(C)C)C(C)C)cs1)c2cc(OC)c(OC)cc2O
- InChI=1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27) Y
- Key:TWHZNAUBXFZMCA-UHFFFAOYSA-N Y
Acotiamide, sold under the brand name Acofide,[2][3] is a medication manufactured and approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.[4] It acts as an acetylcholinesterase inhibitor.
References
- ^ "Acofide (acotiamide hydrochloride hydrate) Tablets Review Report" (PDF). Retrieved 29 December 2016.
- ^ Nowlan ML, Scott LJ (August 2013). "Acotiamide: first global approval". Drugs. 73 (12): 1377–83. doi:10.1007/s40265-013-0100-9. PMID 23881665. S2CID 20383853.
- ^ Matsunaga Y, Tanaka T, Saito Y, Kato H, Takei M (February 2014). "[Pharmacological and clinical profile of acotiamide hydrochloride hydrate (Acofide(®) Tablets 100 mg), a novel therapeutic agent for functional dyspepsia (FD)]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 143 (2): 84–94. doi:10.1254/fpj.143.84. PMID 24531902.
- ^ Matsueda K, Hongo M, Tack J, Aoki H, Saito Y, Kato H (June 2010). "Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia - 100 mg t.i.d. is an optimal dosage". Neurogastroenterology and Motility. 22 (6): 618–e173. doi:10.1111/j.1365-2982.2009.01449.x. PMID 20059698. S2CID 41298446.
- v
- t
- e
Drugs for functional gastrointestinal disorders (A03)
functional
bowel
disorders
Antimuscarinics |
| ||||
---|---|---|---|---|---|
Phosphodiesterase inhibitors | |||||
Acting on serotonin receptors |
| ||||
Other |
and derivatives
(antimuscarinics)
- Tertiary amines: Atropine
- Hyoscyamine
- Quaternary ammonium compounds:
- Cimetropium bromide
- Fentonium bromide
- Methylatropine
- Primarily dopamine antagonists
- 5-HT4 agonists
- Acotiamide
- Ilebopride
- Mosapride
This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e
This article about an amine is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e