Butalamine
Chemical compound
- C04AX23 (WHO)
- N,N-Dibutyl-N'-(3-phenyl-1,2,4-oxadiazol-5-yl)ethane-1,2-diamine
- 22131-35-7
- 30949
- 28712
- 140T9JTG43
- ChEMBL1697825
- DTXSID1022710
- Interactive image
- n1c(onc1c2ccccc2)NCCN(CCCC)CCCC
Butalamine is a vasodilator.[1]
Synthesis
The reaction of benzamidoxime (1) with chlorine and subsequent reaction with cyanamide (3) gives 5-amino-3-phenyl-1,2,4-oxadiazole (4).[2][3][4] Base catalyzed alkylation with dibutylaminoethyl chloride (5) completes the synthesis of butalamine (6).
References
- ^ Sterne J (April 1976). "[Butalamine hydrochloride. A new vasoactive substance]". Fortschritte Der Medizin (in German). 94 (11): 657–9. PMID 823083.
- ^ Aron-samuel Jan Marcel Didier, FR3334M (1965 to Jan Marcel).
- ^ Japan. Pat., 76 108 068, (1976); CA, 87, 5981b
- ^ Aron-Samuel Jan Marcel Didier, Sterne Jean Jacques, U.S. patent 3,338,899 (1967 to).
- v
- t
- e
Peripheral vasodilators (C04)
- Isoxsuprine
- Buphenine
- Bamethan
- Non-selective
- Selective α1-blockers
This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e