GSK3A |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | GSK3A, Gsk3a, 2700086H06Rik, glycogen synthase kinase 3 alpha |
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External IDs | OMIM: 606784; MGI: 2152453; HomoloGene: 88581; GeneCards: GSK3A; OMA:GSK3A - orthologs |
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EC number | 2.7.11.1 |
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Gene location (Human) |
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| Chr. | Chromosome 19 (human)[1] |
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| Band | 19q13.2 | Start | 42,226,225 bp[1] |
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End | 42,242,625 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 A3 | Start | 24,927,683 bp[2] |
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End | 24,937,276 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - ganglionic eminence
- ventricular zone
- right frontal lobe
- right hemisphere of cerebellum
- prefrontal cortex
- cingulate gyrus
- anterior cingulate cortex
- granulocyte
- epithelium of colon
- beta cell
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| Top expressed in | - motor neuron
- primary motor cortex
- superior colliculus
- subiculum
- piriform cortex
- cingulate gyrus
- pontine nuclei
- anterior amygdaloid area
- dorsal tegmental nucleus
- globus pallidus
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - transferase activity
- nucleotide binding
- protein kinase activity
- kinase activity
- protein serine/threonine kinase activity
- tau-protein kinase activity
- protein binding
- ATP binding
- protein kinase binding
- protein kinase A catalytic subunit binding
- signaling receptor binding
- tau protein binding
| Cellular component | - cytosol
- beta-catenin destruction complex
- postsynapse
- mitochondrion
- cytoplasm
- microtubule
- neuronal cell body
- apical dendrite
- proximal dendrite
| Biological process | - positive regulation of protein catabolic process
- phosphorylation
- positive regulation of protein targeting to mitochondrion
- chemical synaptic transmission, postsynaptic
- negative regulation of UDP-glucose catabolic process
- negative regulation of type B pancreatic cell development
- Wnt signaling pathway
- negative regulation of glycogen biosynthetic process
- nervous system development
- negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
- dopamine receptor signaling pathway
- protein phosphorylation
- IRE1-mediated unfolded protein response
- negative regulation of glucose import
- negative regulation of insulin receptor signaling pathway
- regulation of autophagy of mitochondrion
- negative regulation of glycogen (starch) synthase activity
- cellular response to insulin stimulus
- glycogen metabolic process
- negative regulation of signal transduction
- negative regulation of canonical Wnt signaling pathway
- regulation of systemic arterial blood pressure
- cardiac left ventricle morphogenesis
- regulation of gene expression by genetic imprinting
- human ageing
- insulin receptor signaling pathway
- positive regulation of peptidyl-threonine phosphorylation
- cell migration
- negative regulation of TOR signaling
- positive regulation of peptidyl-serine phosphorylation
- cellular response to interleukin-3
- proteasome-mediated ubiquitin-dependent protein catabolic process
- positive regulation of neuron apoptotic process
- hypermethylation of CpG island
- positive regulation of heart contraction
- positive regulation of transcription by RNA polymerase II
- negative regulation of cell growth involved in cardiac muscle cell development
- cellular response to lithium ion
- cellular response to organic cyclic compound
- positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
- negative regulation of dendrite development
- positive regulation of glycogen (starch) synthase activity
- carbohydrate metabolic process
- positive regulation of gene expression
- peptidyl-threonine phosphorylation
- positive regulation of protein ubiquitination
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- excitatory postsynaptic potential
- extrinsic apoptotic signaling pathway
- positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
- positive regulation of amyloid-beta formation
- positive regulation of autophagy
| Sources:Amigo / QuickGO |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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