Protein-coding gene in the species Homo sapiens
MRPS9 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | MRPS9, MRP-S9, RPMS9, S9mt, mitochondrial ribosomal protein S9 |
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External IDs | OMIM: 611975; MGI: 1916777; HomoloGene: 32565; GeneCards: MRPS9; OMA:MRPS9 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 2 (human)[1] |
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| Band | 2q12.1 | Start | 105,038,069 bp[1] |
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End | 105,099,960 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 1 (mouse)[2] |
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| Band | 1|1 B | Start | 42,890,393 bp[2] |
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End | 42,944,843 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - myocardium of left ventricle
- gastrocnemius muscle
- deltoid muscle
- tibialis anterior muscle
- quadriceps femoris muscle
- vastus lateralis muscle
- muscle of thigh
- apex of heart
- mucosa of transverse colon
- Skeletal muscle tissue of rectus abdominis
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| Top expressed in | - Paneth cell
- medullary collecting duct
- atrioventricular junction
- fossa
- atrioventricular valve
- soleus muscle
- condyle
- endocardial cushion
- myocardium of ventricle
- epithelium of lens
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - protein binding
- structural constituent of ribosome
- RNA binding
| Cellular component | - mitochondrial inner membrane
- ribosome
- nucleolus
- mitochondrial small ribosomal subunit
- mitochondrion
| Biological process | - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- mitochondrial translational elongation
- mitochondrial translational termination
- protein biosynthesis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 2: 105.04 – 105.1 Mb | Chr 1: 42.89 – 42.94 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Mitochondrial ribosomal protein S9 (MRPS9), otherwise known as uS9m, is a protein that in humans is encoded by the MRPS9 gene. [5]
Function
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008].
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000135972 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060679 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Mitochondrial ribosomal protein S9". Retrieved 2018-02-11.
Further reading
External links
- Overview of all the structural information available in the PDB for UniProt: P82933 (Human 28S ribosomal protein S9, mitochondrial (MRPS9)) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.