Marinobufagenin
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IUPAC name 3β,5-Dihydroxy-14,15-epoxy-5β,14β-bufa-20,22-dienolide | |
Systematic IUPAC name 5-[(1R,2aR,3aS,3bR,5aS,7S,9aR,9bS,11aR)-5b,7-Dihydroxy-9a,11a-dimethylhexadecahydronaphtho[1′,2′:6,7]indeno[1,7a-b]oxiren-1-yl]-2H-pyran-2-one | |
Other names Marinobufagin, Marinobufagenin | |
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Properties | |
Chemical formula | C24H32O5 |
Molar mass | 400.515 g·mol−1 |
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Occupational safety and health (OHS/OSH): | |
Main hazards | Toxic |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Marinobufagenin (marinobufagin) is a cardiotonic bufadienolide steroid. It can be found in the plasma and urine of human subjects with myocardial infarction, kidney failure, and heart failure.[1] It is also secreted by the toad Bufo rubescens[2] and other related species such as Bufo marinus. It is a vasoconstrictor with effects similar to digitalis.[3]
References
- ^ Tian, Jiang (7 September 2010). "Renal ischemia regulates marinobufagenin release in humans". Hypertension. 56 (5): 914–919. doi:10.1161/hypertensionaha.110.155564. PMC 2959137. PMID 20823380.
- ^ Cunha Filho, GA; Schwartz, CA; Resck, IS; Murta, MM; Lemos, SS; Castro, MS; Kyaw, C; Pires Jr, OR; et al. (2005). "Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens". Toxicon. 45 (6): 777–82. doi:10.1016/j.toxicon.2005.01.017. PMID 15804527.
- ^ Fedorova, OV; Talan, MI; Agalakova, NI; Lakatta, EG; Bagrov, AY (2002). "Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension". Circulation. 105 (9): 1122–7. doi:10.1161/hc0902.104710. PMID 11877366.
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- Toxins
- cardiotoxin
- cytotoxin
- enterotoxin
- hemotoxin
- hepatotoxin
- neurotoxin
- phototoxin
toxins
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Virulence factor |
- Aflatoxin
- Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin)
- beta-Nitropropionic acid
- Citrinin
- Cytochalasin
- Ergotamine
- Fumonisin (Fumonisin B1, Fumonisin B2, Fumonisin B3, Fumonisin B4)
- Gliotoxin
- Ibotenic acid
- Lolitrem B
- Muscimol
- Orellanine
- Ochratoxin
- Patulin
- Phalloidin
- Sterigmatocystin
- Trichothecene
- Vomitoxin
- Zeranol
- Zearalenone
- Amygdalin
- Anisatin
- Antiarin
- Brucine
- Chaconine
- Cicutoxin
- Coniine
- Daphnin
- Delphinine
- Divicine
- Djenkolic acid
- Falcarinol
- Gossypol
- Helenalin
- Ledol
- Linamarin
- Lotaustralin
- Mimosine
- Oenanthotoxin
- Oleandrin
- Persin
- Protoanemonin
- Pseudaconitine
- Retronecine
- Resiniferatoxin
- Scopolamine
- Solamargine
- Solanidine
- Solanine
- Solasodamine
- Solasodine
- Solasonine
- Solauricidine
- Solauricine
- Strychnine
- Swainsonine
- Tagetitoxin
- Tinyatoxin
- Tomatine
- Toxalbumin
- Tutin
toxins
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toxins
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- note: some toxins are produced by lower species and pass through intermediate species
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