NOP58

Protein-coding gene in the species Homo sapiens
NOP58
Identifiers
AliasesNOP58, NOP5, NOP5/HSPC120, NOP58 ribonucleoprotein
External IDsOMIM: 616742; MGI: 1933184; HomoloGene: 7024; GeneCards: NOP58; OMA:NOP58 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for NOP58
Genomic location for NOP58
Band2q33.1Start202,265,736 bp[1]
End202,303,661 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for NOP58
Genomic location for NOP58
Band1|1 C2Start59,724,130 bp[2]
End59,758,203 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic epithelial cell

  • pancreatic ductal cell

  • gingival epithelium

  • sural nerve

  • mucosa of sigmoid colon

  • body of pancreas

  • Achilles tendon

  • tonsil

  • left ovary

  • anterior pituitary
Top expressed in
  • tail of embryo

  • epiblast

  • genital tubercle

  • ventricular zone

  • blastocyst

  • yolk sac

  • embryo

  • embryo

  • morula

  • morula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ATPase binding
  • protein binding
  • TFIID-class transcription factor complex binding
  • snoRNA binding
  • RNA binding
Cellular component
  • small-subunit processome
  • Cajal body
  • pre-snoRNP complex
  • membrane
  • nucleoplasm
  • nucleolus
  • nucleus
  • box C/D RNP complex
  • sno(s)RNA-containing ribonucleoprotein complex
  • fibrillar center
  • cytosol
Biological process
  • ribosome biogenesis
  • snoRNA localization
  • cell growth
  • rRNA processing
  • rRNA modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51602

55989

Ensembl

ENSG00000055044

ENSMUSG00000026020

UniProt

Q9Y2X3

Q6DFW4

RefSeq (mRNA)

NM_015934

NM_018868

RefSeq (protein)

NP_057018

NP_061356

Location (UCSC)Chr 2: 202.27 – 202.3 MbChr 1: 59.72 – 59.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleolar protein 58 is a protein that in humans is encoded by the NOP58 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000055044 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026020 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lyman SK, Gerace L, Baserga SJ (Jan 2000). "Human Nop5/Nop58 is a component common to the box C/D small nucleolar ribonucleoproteins". RNA. 5 (12): 1597–604. doi:10.1017/S1355838299991288. PMC 1369881. PMID 10606270.
  6. ^ Nelson SA, Santora KE, LaRochelle WJ (Sep 2000). "Isolation and characterization of a novel PDGF-induced human gene". Gene. 253 (1): 87–93. doi:10.1016/S0378-1119(00)00232-8. PMID 10925205.
  7. ^ "Entrez Gene: NOP5/NOP58 nucleolar protein NOP5/NOP58".

Further reading

  • Pintard L, Kressler D, Lapeyre B (2000). "Spb1p Is a Yeast Nucleolar Protein Associated with Nop1p and Nop58p That Is Able To Bind S-Adenosyl-l-Methionine In Vitro". Mol. Cell. Biol. 20 (4): 1370–81. doi:10.1128/MCB.20.4.1370-1381.2000. PMC 85287. PMID 10648622.
  • Yang Y, Isaac C, Wang C, et al. (2000). "Conserved Composition of Mammalian Box H/ACA and Box C/D Small Nucleolar Ribonucleoprotein Particles and Their Interaction with the Common Factor Nopp140". Mol. Biol. Cell. 11 (2): 567–77. doi:10.1091/mbc.11.2.567. PMC 14794. PMID 10679015.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Verheggen C, Lafontaine DL, Samarsky D, et al. (2002). "Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments". EMBO J. 21 (11): 2736–45. doi:10.1093/emboj/21.11.2736. PMC 126019. PMID 12032086.
  • Watkins NJ, Dickmanns A, Lührmann R (2003). "Conserved Stem II of the Box C/D Motif Is Essential for Nucleolar Localization and Is Required, Along with the 15.5K Protein, for the Hierarchical Assembly of the Box C/D snoRNP". Mol. Cell. Biol. 22 (23): 8342–52. doi:10.1128/MCB.22.23.8342-8352.2002. PMC 134055. PMID 12417735.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Watkins NJ, Lemm I, Ingelfinger D, et al. (2005). "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex". Mol. Cell. 16 (5): 789–98. doi:10.1016/j.molcel.2004.11.012. hdl:11858/00-001M-0000-0012-EB89-8. PMID 15574333.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
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