PF-06260414
Chemical compound
- US: Investigational new drug
- 6-[(4R)-4-methyl-1,1-dioxo-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile
- 1612755-71-1
- 76071881
- DB15221
- 58824307
- 3I487UHH95
- ChEMBL4297476
- Interactive image
- C[C@@H]1CNS(=O)(=O)N(C1)C2=CC3=C(C=C2)C(=NC=C3)C#N
InChI
- InChI=1S/C14H14N4O2S/c1-10-8-17-21(19,20)18(9-10)12-2-3-13-11(6-12)4-5-16-14(13)7-15/h2-6,10,17H,8-9H2,1H3/t10-/m1/s1
- Key:ZKAVFOXYJCREBQ-SNVBAGLBSA-N
PF-06260414 is a drug which acts as a selective androgen receptor modulator (SARM), and was developed for androgen replacement therapy.[1][2][3]
See also
- AC-262536
- ACP-105
- Enobosarm
- JNJ-28330835
- Ligandrol
References
- ^ Bhattacharya I, Tarabar S, Liang Y, Pradhan V, Owens J, Oemar B (June 2016). "Safety, Pharmacokinetic, and Pharmacodynamic Evaluation After Single and Multiple Ascending Doses of a Novel Selective Androgen Receptor Modulator in Healthy Subjects". Clinical Therapeutics. 38 (6): 1401–1416. doi:10.1016/j.clinthera.2016.03.025. PMID 27085586.
- ^ Ventura E, Gadaj A, Buckley T, Mooney MH (September 2020). "Development of a multi-residue high-throughput UHPLC-MS/MS method for routine monitoring of SARM compounds in equine and bovine blood". Drug Testing and Analysis. 12 (9): 1373–1379. doi:10.1002/dta.2875. PMID 32519780. S2CID 219563612.
- ^ Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P (October 2021). "Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes". Drug Testing and Analysis. 14 (2): 349–370. doi:10.1002/dta.3189. hdl:1854/LU-8740373. PMID 34714606. S2CID 240152623.
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Androgen receptor modulators
Agonists |
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- See also
- Receptor/signaling modulators
- Androgens and antiandrogens
- Estrogen receptor modulators
- Progesterone receptor modulators
- List of androgens and anabolic steroids
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