POLR2F

Protein-coding gene in the species Homo sapiens

POLR2F

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1QKL, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6

Identifiers

Aliases

POLR2F, HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15, polymerase (RNA) II subunit F, RNA polymerase II subunit F, RNA polymerase II, I and III subunit F

External IDs

OMIM: 604414; MGI: 1349393; HomoloGene: 7178; GeneCards: POLR2F; OMA:POLR2F - orthologs

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	22q13.1	Start	37,952,607 bp^[1]
Band	22q13.1	End	38,041,915 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15 E1\|15 37.7 cM	Start	79,025,209 bp^[2]
Band	15 E1\|15 37.7 cM	End	79,035,974 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

C1 segment

tibial nerve

tendon of biceps brachii

apex of heart

right lobe of liver

right auricle

amygdala

left ventricle

anterior pituitary

ganglionic eminence

Top expressed in

yolk sac

morula

morula

otic vesicle

medial ganglionic eminence

endothelial cell of lymphatic vessel

embryo

embryo

ventricular zone

vestibular membrane of cochlear duct

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding RNA polymerase II activity RNA polymerase III activity DNA-directed 5'-3' RNA polymerase activity RNA polymerase I activity
Cellular component	cytosol nucleoplasm RNA polymerase I complex RNA polymerase III complex RNA polymerase II, core complex nucleus fibrillar center
Biological process	termination of RNA polymerase I transcription mRNA splicing, via spliceosome epigenetic maintenance of chromatin in transcription-competent conformation transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway transcription by RNA polymerase III RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcription
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5435


69833

Ensembl


ENSG00000100142


ENSMUSG00000033020

UniProt


P61218


P61219

RefSeq (mRNA)


NM_001301129 NM_001301130 NM_001301131 NM_021974 NM_001363825


NM_027231

RefSeq (protein)


NP_001288058 NP_001288059 NP_001288060 NP_068809 NP_001350754


NP_081507

Location (UCSC)

Chr 22: 37.95 – 38.04 Mb

Chr 15: 79.03 – 79.04 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene.^[5]

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template.^[6]

Interactions

POLR2F has been shown to interact with POLR2C.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100142 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033020 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pusch C, Wang Z, Roe B, et al. (September 1996). "Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity". Genomics. 34 (3): 440–2. doi:10.1006/geno.1996.0312. PMID 8786150.
^ "Entrez Gene: POLR2F polymerase (RNA) II (DNA directed) polypeptide F".
^ Acker J, de Graaff M, Cheynel I, et al. (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27). UNITED STATES: 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.

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