Protein-coding gene in humans
TSPAN8 |
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Identifiers |
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Aliases | TSPAN8, CO-029, TM4SF3, tetraspanin 8 |
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External IDs | OMIM: 600769; MGI: 2384918; HomoloGene: 20968; GeneCards: TSPAN8; OMA:TSPAN8 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 12 (human)[1] |
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| Band | 12q21.1 | Start | 71,125,085 bp[1] |
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End | 71,441,898 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 10 (mouse)[2] |
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| Band | 10|10 D2 | Start | 115,652,737 bp[2] |
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End | 115,685,798 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - mucosa of colon
- mucosa of sigmoid colon
- jejunal mucosa
- mucosa of transverse colon
- mucosa of ileum
- rectum
- duodenum
- pancreatic ductal cell
- bronchial epithelial cell
- gallbladder
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| Top expressed in | - seminal vesicula
- mucous cell of stomach
- epithelium of stomach
- left colon
- pyloric antrum
- crypt of lieberkuhn of small intestine
- Paneth cell
- migratory enteric neural crest cell
- right lung lobe
- ileum
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - integrin binding
- protein binding
| Cellular component | - integral component of membrane
- integral component of plasma membrane
- extracellular exosome
- membrane
- cell surface
| Biological process | - cell surface receptor signaling pathway
- negative regulation of blood coagulation
- spermatogenesis
- regulation of gene expression
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001168679 NM_001168680 NM_146010 |
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RefSeq (protein) | | |
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NP_001162150 NP_001162151 NP_666122 |
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Location (UCSC) | Chr 12: 71.13 – 71.44 Mb | Chr 10: 115.65 – 115.69 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.[5][6]
Function
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.[6]
Clinical significance
Overall survival of ovarian cancer patients was effectively predicted by TSPAN8.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000127324 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034127 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (September 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6833–7. Bibcode:1990PNAS...87.6833S. doi:10.1073/pnas.87.17.6833. PMC 54632. PMID 2395876.
- ^ a b "Entrez Gene: TSPAN8 tetraspanin 8".
- ^ Fekete T, Rásó E, Pete I, Tegze B, Liko I, Munkácsy G, Sipos N, Rigó J, Györffy B (July 2012). "Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples" (PDF). International Journal of Cancer. 131 (1): 95–105. doi:10.1002/ijc.26364. PMID 21858809. S2CID 205944534.
Further reading
- Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Gwynn B, Eicher EM, Peters LL (July 1996). "Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome". Genomics. 35 (2): 389–91. doi:10.1006/geno.1996.0375. PMID 8661157.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 ( Pt 1) (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
- Kanetaka K, Sakamoto M, Yamamoto Y, Yamasaki S, Lanza F, Kanematsu T, Hirohashi S (November 2001). "Overexpression of tetraspanin CO-029 in hepatocellular carcinoma". Journal of Hepatology. 35 (5): 637–42. doi:10.1016/S0168-8278(01)00183-0. PMID 11690710.
- Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, McCaughan GW (September 2003). "Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization". Hepatology. 38 (3): 577–88. doi:10.1053/jhep.2003.50376. PMID 12939584. S2CID 46013740.
- Kuhn S, Koch M, Nübel T, Ladwein M, Antolovic D, Klingbeil P, Hildebrand D, Moldenhauer G, Langbein L, Franke WW, Weitz J, Zöller M (June 2007). "A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression". Molecular Cancer Research. 5 (6): 553–67. doi:10.1158/1541-7786.MCR-06-0384. PMID 17579117.
Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin | |
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Membrane-spanning 4A | - MS4A1
- MS4A2
- MS4A3
- MS4A4A
- MS4A4E
- MS4A5
- MS4A6A
- MS4A6E
- MS4A7
- MS4A8B
- MS4A9
- MS4A10
- MS4A12
- MS4A13
- MS4A14
- MS4A15
- MS4A18
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Myelin | |
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Pulmonary surfactant | |
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Tetraspanin | |
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Other/ungrouped | |
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see also other cell membrane protein disorders |
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