Tampramine
Chemical compound
- In general: uncontrolled
- N,N-Dimethyl-3-(6-phenylpyrido[2,3-b][1,4]benzodiazepin-11-yl)propan-1-amine
- 83166-17-0
83166-18-1 (fumarate)
- 54961
- 49631
- 47GSE5RM8N
- DTXSID00232203
- Interactive image
- CN(C)CCCN1c2ccccc2C(=Nc3c1nccc3)c4ccccc4
Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.[1][2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.[1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.[2]
See also
- Tricyclic antidepressant
References
- ^ a b Kinnier WJ, Tabor RD, Norrell LY (October 1984). "Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake". Biochemical Pharmacology. 33 (19): 3001–5. doi:10.1016/0006-2952(84)90600-2. PMID 6548381.
- ^ a b O'Donnell JM, Seiden LS (1985). "Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate". Psychopharmacology. 87 (3): 283–5. doi:10.1007/BF00432708. PMID 3936083. S2CID 20677730.
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Antidepressants (N06A)
Specific reuptake inhibitors and/or receptor modulators | |||||||||||||||||
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Miscellaneous | |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III