SYNE2 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 4DXS, 4FI9 | | |
Ідентифікатори |
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Символи | SYNE2, EDMD5, NUA, NUANCE, Nesp2, Nesprin-2, SYNE-2, TROPH, spectrin repeat containing nuclear envelope protein 2, KASH2 |
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Зовнішні ІД | OMIM: 608442 MGI: 2449316 HomoloGene: 56700 GeneCards: SYNE2 |
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Онтологія гена |
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Молекулярна функція | • actin filament binding • GO:0001948, GO:0016582 protein binding • actin binding |
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Клітинна компонента | • цитоплазма • integral component of membrane • ядерна мембрана • nuclear envelope • мембрана • focal adhesion • клітинна мембрана • sarcoplasmic reticulum • нуклеоплазма • aggresome • міжклітинні контакти • міофібрила • Z discdkac • meiotic nuclear membrane microtubule tethering complex • мітохондрія • sarcoplasmic reticulum membrane • intermediate filament cytoskeleton • nuclear lumen • екзосома • nuclear outer membrane • lamellipodium membrane • цитоскелет • клітинне ядро • filopodium membrane • центросома |
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Біологічний процес | • fibroblast migration • nuclear envelope organization • nuclear migration along microfilament • positive regulation of cell migration • centrosome localization • nuclear migration • establishment or maintenance of cell polarity • protein localization to nucleus • nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration • regulation of cilium assembly • centriole-centriole cohesion |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_015180 NM_182910 NM_182912 NM_182913 NM_182914 |
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RefSeq (білок) | | NP_055995 NP_878914 NP_878917 NP_878918 |
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Локус (UCSC) | Хр. 14: 63.76 – 64.23 Mb | Хр. 12: 75.86 – 76.16 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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SYNE2 (англ. Spectrin repeat containing nuclear envelope protein 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 14-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 6 885 амінокислот, а молекулярна маса — 796 442[4].
Послідовність амінокислот
10 | | 20 | | 30 | | 40 | | 50 |
MASSPELPTE | | DEQGSWGIDD | | LHISLQAEQE | | DTQKKAFTCW | | INSQLARHTS |
PSVISDLFTD | | IKKGHVLLDL | | LEVLSGQQLP | | RDKGSNTFQC | | RINIEHALTF |
LRNRSIKLIN | | IHVTDIIDGN | | PSIILGLIWT | | IILHFHIEKL | | AQTLSCNYNQ |
PSLDDVSVVD | | SSPASSPPAK | | KCSKVQARWQ | | MSARKALLLW | | AQEQCATYES |
VNVTDFKSSW | | RNGMAFLAII | | HALRPDLIDM | | KSVKHRSNKD | | NLREAFRIAE |
QELKIPRLLE | | PEDVDVVDPD | | EKSIMTYVAQ | | FLQYSKDAPG | | TGEEAQGKVK |
DAMGWLTLQK | | EKLQKLLKDS | | ENDTYFKKYN | | SLLSFMESFN | | EEKKSFLDVL |
SIKRDLDELD | | KDHLQLREAW | | DGLDHQINAW | | KIKLNYALPP | | PLHQTEAWLQ |
EVEELMDEDL | | SASQDHSQAV | | TLIQEKMTLF | | KSLMDRFEHH | | SNILLTFENK |
DENHLPLVPP | | NKLEEMKRRI | | NNILEKKFIL | | LLEFHYYKCL | | VLGLVDEVKS |
KLDIWNIKYG | | SRESVELLLE | | DWHKFIEEKE | | FLARLDTSFQ | | KCGEIYKNLA |
GECQNINKQY | | MMVKSDVCMY | | RKNIYNVKST | | LQKVLACWAT | | YVENLRLLRA |
CFEETKKEEI | | KEVPFETLAQ | | WNLEHATLNE | | AGNFLVEVSN | | DVVGSSISKE |
LRRLNKRWRK | | LVSKTQLEMN | | LPLMIKKQDQ | | PTFDNSGNIL | | SKEEKATVEF |
STDMSVELPE | | NYNQNIKAGE | | KHEKENEEFT | | GQLKVAKDVE | | KLIGQVEIWE |
AEAKSVLDQD | | DVDTSMEESL | | KHLIAKGSMF | | DELMARSEDM | | LQMDIQNISS |
QESFQHVLTT | | GLQAKIQEAK | | EKVQINVVKL | | IAALKNLTDV | | SPDLDIRLKM |
EESQKELESY | | MMRAQQLLGQ | | RESPGELISK | | HKEALIISNT | | KSLAKYLKAV |
EELKNNVTED | | IKMSLEEKSR | | DVCAKWESLH | | HELSLYVQQL | | KIDIEKGKLS |
DNILKLEKQI | | NKEKKLIRRG | | RTKGLIKEHE | | ACFSEEGCLY | | QLNHHMEVLR |
ELCEELPSQK | | SQQEVKRLLK | | DYEQKIERLL | | KCASEIHMTL | | QPTAGGTSKN |
EGTITTSENR | | GGDPHSEAPF | | AKSDNQPSTE | | KAMEPTMKFS | | LASVLRPLQE |
ESIMEKDYSA | | SINSLLERYD | | TYRDILEHHL | | QNNKFRITSD | | FSSEEDRSSS |
CLQAKLTDLQ | | VIKNETDARW | | KEFEIISLKL | | ENHVNDIKKP | | FVIKERDTLK |
ERERELQMTL | | NTRMESLETA | | LRLVLPVEKA | | SLLLCGSDLP | | LHKMAIQGFH |
LIDADRIYQH | | LRNIQDSIAK | | QIEICNRLEE | | PGNFVLKELH | | PFDLHAMQNI |
ILKYKTQFEG | | MNHRVQRSED | | TLKALEDFLA | | SLRTAKLSAE | | PVTDLSASDT |
QVAQENTLTV | | KNKEGEIHLM | | KDKAKHLDKC | | LKMLDMSFKD | | AERGDDTSCE |
NLLDAFSIKL | | SETHGYGVQE | | EFTEENKLLE | | ACIFKNNELL | | KNIQDVQSQI |
SKIGLKDPTV | | PAVKHRKKSL | | IRLDKVLDEY | | EEEKRHLQEM | | ANSLPHFKDG |
REKTVNQQCQ | | NTVVLWENTK | | ALVTECLEQC | | GRVLELLKQY | | QNFKSILTTL |
IQKEESVISL | | QASYMGKENL | | KKRIAEIEIV | | KEEFNEHLEV | | VDKINQVCKN |
LQFYLNKMKT | | FEEPPFEKEA | | NIIVDRWLDI | | NEKTEDYYEN | | LGRALALWDK |
LFNLKNVIDE | | WTEKALQKME | | LHQLTEEDRE | | RLKEELQVHE | | QKTSEFSRRV |
AEIQFLLQSS | | EIPLELQVME | | SSILNKMEHV | | QKCLTGESNC | | HALSGSTAEL |
REDLDQAKTQ | | IGMTESLLKA | | LSPSDSLEIF | | TKLEEIQQQI | | LQQKHSMILL |
ENQIGCLTPE | | LSELKKQYES | | VSDLFNTKKS | | VLQDHFSKLL | | NDQCKNFNDW |
FSNIKVNLKE | | CFESSETKKS | | VEQKLQKLSD | | FLTLEGRNSK | | IKQVDSVLKH |
VKKHLPKAHV | | KELISWLVGQ | | EFELEKMESI | | CQARAKELED | | SLQQLLRLQD |
DHRNLRKWLT | | NQEEKWKGME | | EPGEKTELFC | | QALARKREQF | | ESVAQLNNSL |
KEYGFTEEEE | | IIMEATCLMD | | RYQTLLRQLS | | EIEEEDKLLP | | TEDQSFNDLA |
HDVIHWIKEI | | KESLMVLNSS | | EGKMPLEERI | | QKIKEIILLK | | PEGDARIETI |
MKQAESSEAP | | LVQKTLTDIS | | NQWDNTLHLA | | STYLSHQEKL | | LLEGEKYLQS |
KEDLRLMLIE | | LKKKQEAGFA | | LQHGLQEKKA | | QLKIYKKFLK | | KAQDLTSLLK |
ELKSQGNYLL | | ECTKNPSFSE | | EPWLEIKHLH | | ESLLQQLQDS | | VQNLDGHVRE |
HDSYQVCVTD | | LNTTLDNFSK | | EFVSFSDKPV | | DQIAVEEKLQ | | KLQELENRLS |
LQDGTLKKIL | | ALAKSVKQNT | | SSVGQKIIKD | | DIKSLQCKQK | | DLENRLASAK |
QEMECCLNSI | | LKSKRSTEKK | | GKFTLPGREK | | QATSDVQEST | | QESAAVEKLE |
EDWEINKDSA | | VEMAMSKQLS | | LNAQESMKNT | | EDERKVNELQ | | NQPLELDTML |
RNEQLEEIEK | | LYTQLEAKKA | | AIKPLEQTEC | | LNKTETGALV | | LHNIGYSAQH |
LDNLLQALIT | | LKKNKESQYC | | VLRDFQEYLA | | AVESSMKALL | | TDKESLKVGP |
LDSVTYLDKI | | KKFIASIEKE | | KDSLGNLKIK | | WENLSNHVTD | | MDKKLLESQI |
KQLEHGWEQV | | EQQIQKKYSQ | | QVVEYDEFTT | | LMNKVQDTEI | | SLQQQQQHLQ |
LRLKSPEERA | | GNQSMIALTT | | DLQATKHGFS | | VLKGQAELQM | | KRIWGEKEKK |
NLEDGINNLK | | KQWETLEPLH | | LEAENQIKKC | | DIRNKMKETI | | LWAKNLLGEL |
NPSIPLLPDD | | ILSQIRKCKV | | THDGILARQQ | | SVESLAEEVK | | DKVPSLTTYE |
GSDLNNTLED | | LRNQYQMLVL | | KSTQRSQQLE | | FKLEERSNFF | | AIIRKFQLMV |
QESETLIIPR | | VETAATEAEL | | KHHHVTLEAS | | QKELQEIDSG | | ISTHLQELTN |
IYEELNVFER | | LFLEDQLKNL | | KIRTNRIQRF | | IQNTCNEVEH | | KIKFCRQFHE |
KTSALQEEAD | | SIQRNELLLN | | QEVNKGVKEE | | IYNLKDRLTA | | IKCCILQVLK |
LKKVFDYIGL | | NWDFSQLDQL | | QTQVFEKEKE | | LEEKIKQLDT | | FEEEHGKYQA |
LLSKMRAIDL | | QIKKMTEVVL | | KAPDSSPESR | | RLNAQILSQR | | IEKAKCLCDE |
IIKKLNENKT | | FDDSFKEKEI | | LQIKLNAEEN | | DKLYKVLQNM | | VLELSPKELD |
EKNCQDKLET | | SLHVLNQIKS | | QLQQPLLINL | | EIKHIQNEKD | | NCEAFQEQVW |
AEMCSIKAVT | | AIEKQREENS | | SEASDVETKL | | REFEDLQMQL | | NTSIDLRTNV |
LNDAYENLTR | | YKEAVTRAVE | | SITSLEAIII | | PYRVDVGNPE | | ESLEMPLRKQ |
EELESTVAHI | | QDLTEKLGMI | | SSPEAKLQLQ | | YTLQELVSKN | | SAMKEAFKAQ |
ETEAERYLEN | | YKCYRKMEED | | IYTNLSKMET | | VLGQSMSSLP | | LSYREALERL |
EQSKALVSNL | | ISTKEELMKL | | RQILRLLRLR | | CTENDGICLL | | KIVSALWEKW |
LSLLEAAKEW | | EMWCEELKQE | | WKFVSEEIER | | EAIILDNLQE | | ELPEISKTKE |
AATTEELSEL | | LDCLCQYGEN | | VEKQQLLLTL | | LLQRIRSIQN | | VPESSGAVET |
VPAFQEITSM | | KERCNKLLQK | | VQKNKELVQT | | EIQERHSFTK | | EIIALKNFFQ |
QTTTSFQNMA | | FQDHPEKSEQ | | FEELQSILKK | | GKLTFENIME | | KLRIKYSEMY |
TIVPAEIESQ | | VEECRKALED | | IDEKISNEVL | | KSSPSYAMRR | | KIEEINNGLH |
NVEKMLQQKS | | KNIEKAQEIQ | | KKMWDELDLW | | HSKLNELDSE | | VQDIVEQDPG |
QAQEWMDNLM | | IPFQQYQQVS | | QRAECRTSQL | | NKATVKMEEY | | SDLLKSTEAW |
IENTSHLLAN | | PADYDSLRTL | | SHHASTVQMA | | LEDSEQKHNL | | LHSIFMDLED |
LSIIFETDEL | | TQSIQELSNQ | | VTALQQKIME | | SLPQIQRMAD | | DVVAIESEVK |
SMEKRVSKIK | | TILLSKEIFD | | FSPEEHLKHG | | EVILENIRPM | | KKTIAEIVSY |
QVELRLPQTG | | MKPLPVFQRT | | NQLLQDIKLL | | ENVTQEQNEL | | LKVVIKQTNE |
WDEEIENLKQ | | ILNNYSAQFS | | LEHMSPDQAD | | KLPQLQGEIE | | RMEKQILSLN |
QRKEDLLVDL | | KATVLNLHQH | | LKQEQEGVER | | DRLPAVTSEE | | GGVAERDASE |
RKLNRRGSMS | | YLAAVEEEVE | | ESSVKSDNGD | | EKAEPSPQSW | | SSLWKHDKDM |
EEDRASSSSG | | TIVQEAYGKI | | STSDNSMAQI | | LTPDSLNTEQ | | GPECSLRPNQ |
TEEGTTPPIE | | ADTLDSSDAQ | | GGLEPRVEKT | | RPEPTEVLHA | | CKTQVAELEL |
WLQQANVAVE | | PETLNADMQQ | | VLEQQLVGCQ | | AMLTEIEHKV | | AFLLETCKDQ |
GLGDNGATQH | | EAEALSLKLK | | TVKCNLEKVQ | | MMLQEKHSED | | QHPTILKKSS |
EPEHQEALQP | | VNLSELESIV | | TERPQFSRQK | | DFQQQQVLEL | | KPMEQKDFIK |
FIEFNAKKMW | | PQYCQHDNDT | | TQESSASNQA | | SSPENDVPDS | | ILSPQGQNGD |
KWQYLHHELS | | SKIKLPLPQL | | VEPQVSTNMG | | ILPSVTMYNF | | RYPTTEELKT |
YTTQLEDLRQ | | EASNLQTQEN | | MTEEAYINLD | | KKLFELFLTL | | SQCLSSVEEM |
LEMPRLYRED | | GSGQQVHYET | | LALELKKLYL | | ALSDKKGDLL | | KAMTWPGENT |
NLLLECFDNL | | QVCLEHTQAA | | AVCRSKSLKA | | GLDYNRSYQN | | EIKRLYHQLI |
KSKTSLQQSL | | NEISGQSVAE | | QLQKADAYTV | | ELENAESRVA | | KLRDEGERLH |
LPYALLQEVY | | KLEDVLDSMW | | GMLRARYTEL | | SSPFVTESQQ | | DALLQGMVEL |
VKIGKEKLAH | | GHLKQTKSKV | | ALQAQIENHK | | VFFQKLVADM | | LLIQAYSAKI |
LPSLLQNRET | | FWAEQVTEVK | | ILEEKSRQCG | | MKLQSLLQKW | | EEFDENYASL |
EKDLEILIST | | LPSVSLVEET | | EERLVERISF | | YQQIKRNIGG | | KHARLYQTLN |
EGKQLVASVS | | CPELEGQIAK | | LEEQWLSLNK | | KIDHELHRLQ | | ALLKHLLSYN |
RDSDQLTKWL | | ESSQHTLNYW | | KEQSLNVSQD | | LDTIRSNINN | | FFEFSKEVDE |
KSSLKTAVIS | | IGNQLLHLKE | | TDTATLRASL | | AQFEQKWTML | | ITQLPDIQEK |
LHQLQMEKLP | | SRKAITEMIS | | WMNNVEHQTS | | DEDSVHSPSS | | ASQVKHLLQK |
HKEFRMEMDY | | KQWIVDFVNQ | | SLLQLSTCDV | | ESKRYERTEF | | AEHLGEMNRQ |
WHRVHGMLNR | | KIQHLEQLLE | | SITESENKIQ | | ILNNWLEAQE | | ERLKTLQKPE |
SVISVQKLLL | | DCQDIENQLA | | IKSKALDELK | | QSYLTLESGA | | VPLLEDTASR |
IDELFQKRSS | | VLTQVNQLKT | | SMQSVLQEWK | | IYDQLYDEVN | | MMTIRFWYCM |
EHSKPVVLSL | | ETLRCQVENL | | QSLQDEAESS | | EGSWEKLQEV | | IGKLKGLCPS |
VAEIIEEKCQ | | NTHKRWTQVN | | QAIADQLQKA | | QSLLQLWKAY | | SNAHGEAAAR |
LKQQEAKFQQ | | LANISMSGNN | | LAEILPPALQ | | DIKELQHDVQ | | KTKEAFLQNS |
SVLDRLPQPA | | ESSTHMLLPG | | PLHSLQRAAY | | LEKMLLVKAN | | EFEFVLSQFK |
DFGVRLESLK | | GLIMHEEENL | | DRLHQQEKEN | | PDSFLNHVLA | | LTAQSPDIEH |
LNEVSLKLPL | | SDVAVKTLQN | | MNRQWIRATA | | TALERCSELQ | | GIGLNEKFLY |
CCEKWIQLLE | | KIEEALKVDV | | ANSLPELLEQ | | QKTYKMLEAE | | VSINQTIADS |
YVTQSLQLLD | | TTEIENRPEF | | ITEFSKLTDR | | WQNAVQGVRQ | | RKGDVDGLVR |
QWQDFTTSVE | | NLFRFLTDTS | | HLLSAVKGQE | | RFSLYQTRSL | | IHELKNKEIH |
FQRRRTTCAL | | TLEAGEKLLL | | TTDLKTKESV | | GRRISQLQDS | | WKDMEPQLAE |
MIKQFQSTVE | | TWDQCEKKIK | | ELKSRLQVLK | | AQSEDPLPEL | | HEDLHNEKEL |
IKELEQSLAS | | WTQNLKELQT | | MKADLTRHVL | | VEDVMVLKEQ | | IEHLHRQWED |
LCLRVAIRKQ | | EIEDRLNTWV | | VFNEKNKELC | | AWLVQMENKV | | LQTADISIEE |
MIEKLQKDCM | | EEINLFSENK | | LQLKQMGDQL | | IKASNKSRAA | | EIDDKLNKIN |
DRWQHLFDVI | | GSRVKKLKET | | FAFIQQLDKN | | MSNLRTWLAR | | IESELSKPVV |
YDVCDDQEIQ | | KRLAEQQDLQ | | RDIEQHSAGV | | ESVFNICDVL | | LHDSDACANE |
TECDSIQQTT | | RSLDRRWRNI | | CAMSMERRMK | | IEETWRLWQK | | FLDDYSRFED |
WLKSAERTAA | | CPNSSEVLYT | | SAKEELKRFE | | AFQRQIHERL | | TQLELINKQY |
RRLARENRTD | | TASRLKQMVH | | EGNQRWDNLQ | | RRVTAVLRRL | | RHFTNQREEF |
EGTRESILVW | | LTEMDLQLTN | | VEHFSESDAD | | DKMRQLNGFQ | | QEITLNTNKI |
DQLIVFGEQL | | IQKSEPLDAV | | LIEDELEELH | | RYCQEVFGRV | | SRFHRRLTSC |
TPGLEDEKEA | | SENETDMEDP | | REIQTDSWRK | | RGESEEPSSP | | QSLCHLVAPG |
HERSGCETPV | | SVDSIPLEWD | | HTGDVGGSSS | | HEEDEEGPYY | | SALSGKSISD |
GHSWHVPDSP | | SCPEHHYKQM | | EGDRNVPPVP | | PASSTPYKPP | | YGKLLLPPGT |
DGGKEGPRVL | | NGNPQQEDGG | | LAGITEQQSG | | AFDRWEMIQA | | QELHNKLKIK |
QNLQQLNSDI | | SAITTWLKKT | | EAELEMLKMA | | KPPSDIQEIE | | LRVKRLQEIL |
KAFDTYKALV | | VSVNVSSKEF | | LQTESPESTE | | LQSRLRQLSL | | LWEAAQGAVD |
SWRGGLRQSL | | MQCQDFHQLS | | QNLLLWLASA | | KNRRQKAHVT | | DPKADPRALL |
ECRRELMQLE | | KELVERQPQV | | DMLQEISNSL | | LIKGHGEDCI | | EAEEKVHVIE |
KKLKQLREQV | | SQDLMALQGT | | QNPASPLPSF | | DEVDSGDQPP | | ATSVPAPRAK |
QFRAVRTTEG | | EEETESRVPG | | STRPQRSFLS | | RVVRAALPLQ | | LLLLLLLLLA |
CLLPSSEEDY | | SCTQANNFAR | | SFYPMLRYTN | | GPPPT |
Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах, як ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з молекулою актину. Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, ядрі, мембрані, мітохондрії, клітинних контактах, саркоплазматичному ретикулумі.
Література
- Zhang Q., Ragnauth C., Greener M.J., Shanahan C.M., Roberts R.G. (2002). The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300. Genomics. 80: 473—481. PMID 12408964 DOI:10.1006/geno.2002.6859
- Rajgor D., Mellad J.A., Autore F., Zhang Q., Shanahan C.M. (2012). Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds. PLoS ONE. 7: E40098—E40098. PMID 22768332 DOI:10.1371/journal.pone.0040098
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Schirmer E.C., Florens L., Guan T., Yates J.R. III, Gerace L. (2003). Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science. 301: 1380—1382. PMID 12958361 DOI:10.1126/science.1088176
- Stewart-Hutchinson P.J., Hale C.M., Wirtz D., Hodzic D. (2008). Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. Exp. Cell Res. 314: 1892—1905. PMID 18396275 DOI:10.1016/j.yexcr.2008.02.022
- Luxton G.W., Gomes E.R., Folker E.S., Vintinner E., Gundersen G.G. (2010). Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science. 329: 956—959. PMID 20724637 DOI:10.1126/science.1189072
Примітки
- ↑ Human PubMed Reference:.
- ↑ Mouse PubMed Reference:.
- ↑ HUGO Gene Nomenclature Commitee, HGNC:17084 (англ.) . Процитовано 11 вересня 2017.
{{cite web}}
: Обслуговування CS1: Сторінки з параметром url-status, але без параметра archive-url (посилання) - ↑ UniProt, Q8WXH0 (англ.) . Архів оригіналу за 7 листопада 2017. Процитовано 11 вересня 2017.
Див. також
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