Selenophos
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Preferred IUPAC name Se-[2-(Diethylamino)ethyl] O-ethyl ethylphosphonoselenoate | |
Other names Seleno-VE[2] | |
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InChI
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Properties | |
Chemical formula | C10H24NO2PSe |
Molar mass | 300.252 g·mol−1 |
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Lethal dose or concentration (LD, LC): | |
LD50 (median dose) | 21 μg/kg (mouse, subcutaneous) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Selenophos is an extremely potent organophosphate acetylcholinesterase inhibitor.[3] It is the selenium analog of the VE nerve agent.
See also
- VE (nerve agent)
References
- ^ Nachmansohn, David (1 July 1969). "Proteins of Excitable Membranes". The Journal of General Physiology. 54 (1): 187–224. doi:10.1085/jgp.54.1.187. PMC 2225914. PMID 19873642.
- ^ Mager, Peter P. (1984). Multidimensional pharmacochemistry : design of safer drugs. Orlando: Academic Press. p. 354. ISBN 978-0-12-465020-6.
- ^ Akerfeldt, Stig.; Fagerlind, Lars. (January 1967). "Selenophosphorus Compounds as Powerful Cholinesterase Inhibitors". Journal of Medicinal Chemistry. 10 (1): 115–116. doi:10.1021/jm00313a032. PMID 6031689.
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Acetylcholine metabolism and transport modulators
(modulators)
(modulators)
CHTTooltip Choline transporter |
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VAChTTooltip Vesicular acetylcholine transporter |
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(modulators)
Inhibitors |
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Enhancers |
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- See also
- Receptor/signaling modulators
- Muscarinic acetylcholine receptor modulators
- Nicotinic acetylcholine receptor modulators
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