Thioperamide
Chemical compound
- none
- N-Cyclohexyl-4-(1H-imidazol-4-yl)piperidine-1-carbothioamide
- 106243-16-7 N
- 3035905
- 1267
- 2300031 Y
- II4319BWUI
- ChEMBL260374 Y
- DTXSID50147555
- Interactive image
- S=C(NC1CCCCC1)N3CCC(c2cnc[nH]2)CC3
InChI
- InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) Y
- Key:QKDDJDBFONZGBW-UHFFFAOYSA-N Y
Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier.[1] It was used by Jean-Charles Schwartz in his early experiments regarding the H3 receptor.[2] Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine. The drug enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.
Its action on H3 receptors is thought to promote wakefulness and improve memory consolidation.
See also
- H3 receptor antagonist
References
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Histamine receptor modulators
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- See also
- Receptor/signaling modulators
- Monoamine metabolism modulators
- Monoamine reuptake inhibitors
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
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