BMPR1A |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 3QB4, 1ES7, 1REW, 2GOO, 2H62, 2H64, 2K3G, 2QJ9, 2QJA, 2QJB, 3NH7 | | |
Ідентифікатори |
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Символи | BMPR1A, 10q23del, ACVRLK3, ALK3, CD292, SKR5, bone morphogenetic protein receptor type 1A |
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Зовнішні ІД | OMIM: 601299 MGI: 1338938 HomoloGene: 20911 GeneCards: BMPR1A |
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Пов'язані генетичні захворювання |
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juvenile polyposis syndrome, hereditary mixed polyposis syndrome[1] |
Онтологія гена |
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Молекулярна функція | • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • зв'язування з іоном металу • kinase activity • protein serine/threonine kinase activity • transmembrane receptor protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • SMAD binding • ATP binding • BMP receptor activity • transforming growth factor beta-activated receptor activity • transforming growth factor beta receptor activity, type I • growth factor binding |
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Клітинна компонента | • integral component of membrane • HFE-transferrin receptor complex • мембрана • клітинна мембрана • neuronal cell body • дендрит (нейробіологія) • caveola • external side of plasma membrane • integral component of plasma membrane • receptor complex • cell surface |
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Біологічний процес | • somitogenesis • pattern specification process • roof of mouth development • диференціація клітин • pituitary gland development • endoderm development • chondrocyte differentiation • neural crest cell development • lateral mesoderm development • lung development • positive regulation of bone mineralization • embryonic organ development • paraxial mesoderm structural organization • positive regulation of epithelial cell proliferation • фосфорилювання • negative regulation of neurogenesis • positive regulation of pathway-restricted SMAD protein phosphorylation • mesoderm formation • ectoderm development • embryonic digit morphogenesis • heart morphogenesis • cellular response to BMP stimulus • in utero embryonic development • BMP signaling pathway • hindlimb morphogenesis • нейробіологія розвитку • dorsal/ventral axis specification • regulation of lateral mesodermal cell fate specification • stem cell population maintenance • odontogenesis of dentin-containing tooth • Mullerian duct regression • endocardial cushion formation • protein phosphorylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • cartilage development • positive regulation of osteoblast differentiation • developmental growth • transmembrane receptor protein serine/threonine kinase signaling pathway • positive regulation of mesenchymal cell proliferation • heart formation • neural plate pattern specification • embryonic morphogenesis • mesendoderm development • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • regulation of cellular senescence • neural plate mediolateral regionalization • dorsal/ventral pattern formation • transforming growth factor beta receptor signaling pathway • positive regulation of SMAD protein signal transduction • anterior/posterior pattern specification • paraxial mesoderm development • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of smooth muscle cell migration • BMP signaling pathway involved in heart development • regulation of cardiac muscle cell apoptotic process • outflow tract septum morphogenesis • outflow tract morphogenesis • cardiac conduction system development • mitral valve morphogenesis • tricuspid valve morphogenesis • endocardial cushion morphogenesis • cardiac right ventricle morphogenesis • ventricular trabecula myocardium morphogenesis • ventricular compact myocardium morphogenesis • dorsal aorta morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of cardiac muscle cell proliferation • positive regulation of cardiac muscle cell proliferation • pharyngeal arch artery morphogenesis • positive regulation of cardiac ventricle development • positive regulation of vascular associated smooth muscle cell proliferation • fibrous ring of heart morphogenesis • regulation of neural crest cell differentiation |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 10: 86.76 – 86.93 Mb | Хр. 14: 34.13 – 34.23 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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